Volume 54 (2004) Issue: 2004 No#2-3

EVALUTION OF THE GENOTOXIC EFFECTS OF TIAMULIN S_ IN VIVO

Author(s): Marković Biljana, Stanimirović Z, Djelić N

Keywords:Chromosomal aberrations, bone marrow, mouse, Tiamulin S, testicles

In this work the genotoxic effect of the antibiotic preparation Tiamulin S was investigated. The experiments were done in vivo using cytogenetic analysis on BALB/c mouse bone marrow cells. The occurrence of chromosomal alterations was monitored in bone marrow and germ cells. The clastogenic effect of Tiamulin S was monitored at three doses (0.01 ml/kg, 0.2 ml/kg and 0.4 ml/kg) through eight experimental cycles. The results obtained showed that Tiamulin S induces kariotype changes including both numerical (aneuploidies and polyploidies) and structural chromosomal aberrations (lesions, breaks and Robertsonian translocations). Thus, Tiamulin S exerts genotoxic potential. In addition, a clear dose-response effect was observed in this investigation.