Volume 66 (2016) Issue: 2016 No#4

Atipamezole attenuated telazol/xylazine-induced expression of c-fos in rat thalamencephal and cerebralcortex

Author(s): Bai-Shuang Yin, Li Gao, Lian-Jun Fu, Ying Fu, Wan-Li Sha, Guo-Jiang Li, Hong-Bin Wang

Keywords:atipamezole, telazol, xylazine, rat, c-fos, brain

The aim of this study was to assess whether atipamezole can restrain telazol/xylazine induced expression of c-fos in the rat brain. Rats were injected with a mixture of 13.81 mg/kg telazol and 5.21 mg/kg xylazine, following 10 min later 0.522 mg/kg atipamezole. Thereon, the thalamencephal and cerebral cortex were removed one hour after the last injection. The level of Fos protein was measured in the brain tissue by Western-blot. The results revealed that atipamezole attenuates telazol/xylazine induction of c-fos expression in the thalamencephal and cerebral cortex. The results indicated that atipamezole is able to inhibit telazol/xylazine-induced c-fos expression in the rat brain, thus protecting it from nerve damage.