Volume 60 (2010) Issue: 2010 No#1

Effects of local application of platelet-rich plasma and guided tissue regeneration on stability of implants

Author(s): Duka M, Lazić Z, Bubalo Marija, Tatić Z, Đurđević D, Matić Smiljana

Keywords:dogs, dental implant, PRP, guided tissue regeneration, early implant insertion

Osseointegration is a result of cellular migration, differentiation, bone formation, and bone remodelling on the surface of an implant. Each of these processes depends on platelets and blood coagulum. Platelet-rich plasma (PRP) is used to improve osseointegration and stability of implants. It is a blood fraction produced in a centrifuge which contains a high concentration of platelets. Platelets contain numerous growth factors which influence tissue reactions. The aim of the research is to test clinically the influence of PRP and guided tissue regeneration in bone defects on dental implant stability with early insertion. An experimental study has been done on 10 experimental dogs. 40 BCT implants were inserted, 4 for each dog (two on the left side and two on the right side, with guided tissue regeneration). Mobility of the implants was measured with the Periotest tool, first immediately after insertion and then 10 weeks after insertion. Results of measuring implant mobility according to the Periotest scale showed that all four groups of implants can be classified as belonging to the 0 degree implant mobility group. On the basis of the results we conclude that the mobility of dental implants was lowest in the protocol where PRP was applied combined with bovine deproteinized bone and resorbable membrane of bovine origin.