Volume 56 (2006) Issue: 2006 No#2-3

L-arginine and physostigmine in hemorrhagic shock: lack of evidence for synergism

Author(s): Gopčević Kristina, Gojgić-Cvijović Gordana, Pavlović Mirjana, Milićević Živana, Stevanović D

Keywords:ionophores, myocardium, inotropic

The effect of some membrane active ionophoric antibiotics on the amplitude of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin, polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38
mol/L exerts a positive inotropic effect with its maximal value (+29%) 15 minutes after application. Amphotericin B in a concentration of 1.08
mol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84
mol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application.