Volume 56 (2006) Issue: 2006 No#2-3

L-arginine and physostigmine in hemorrhagic shock: lack of evidence for synergism

Author(s): Gopčević Kristina, Gojgić-Cvijović Gordana, Pavlović Mirjana, Milićević Živana, Stevanović D

Keywords:ionophores, myocardium, inotropic

The effect of some membrane active ionophoric antibiotics on the amplitude of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin, polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38 mol/L exerts a positive inotropic effect with its maximal value (+29%) 15 minutes after application. Amphotericin B in a concentration of 1.08 mol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84 mol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application.

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ISSN: 0567-8315

eISSN: 1820-7448

Journal Impact Factor 2020: 0.800

5-Year Impact Factor: 0.857

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