Volume 55 (2005) Issue: 2005 No#2-3

The prefrontal cortex blood supply in Cercopithecus aethiops - New approach to the nonprimate model of schizophrenia

Author(s): Filipović B, Nikolić Valentina, Stojić V, Lešić A, Teofilovski-Parapid Gordana

Keywords:Prefrontal cortex, blood supply, Cercopithecus Aethiops, schizophrenia, non - human primates model

Establishing a non – human prefrontal cortex schizophrenia studying model has been a subject of interest in the past decade. Authors intended to contribute to this model with the study of the blood supply of the prefrontal cortex of Cercopithecus Aethiops. Hence, we have microdissected 24 formaldehyde – ethanol fixed brains (48 hemispheres) of adult Cercopithecus Aethiops in order to reveal the origin, calibers and pathway of the prefrontal branches. On 22 of 24 brains, prefrontal rami originated from the dorsal terminal branch of the middle cerebral artery by a common arterial trunk, while on two brains they occured as “early cortical branches” from the terminal part of the middle cerebral artery. The average caliber of the common trunk on both sides was approximately 500
m, or about a half of the “mother artery”, without significant left – right asymmetries. The adequacy of the vascular pattern of the prefrontal cortex of the Cercopithecus Aethiops for future experimental investigations of schizophrenia has also been discussed.