Volume 66 (2016) Issue: 2016 No#3

Characterization of Intor:Swiss albino mice adopted in the Institute of Virology, Vaccines and Sera – Torlak, Belgrade in the early twentieth century

Author(s): Živković Irena, Rajnpreht Irena, Minić Rajna, Mitić Katarina, Aleksić Iva, Kadrić Jaminka, Petrušić Vladimir

Keywords:laboratory animals, outbtred, Swiss mice, IgG2c.

The Institute of Virology, Vaccines and Sera Torlak was established in 1927, while the first vaccine was produced in the Institute in 1930. Vaccines production implies using experimental animals, including mice, in in-process controls. The laboratory mice which have been in use in Torlak Institute from the very beginning belong to Swiss albino outbred stock. This stock, which has been in use for more than 80 years contains a large number of mice maintained at all times, was recently named Intor:Swiss. Biological characteristics of Intor:Swiss stock, are presented in this paper for the first time. Taking into account the presented characteristics, the Institute Torlak`s Swiss mice are suitable for use in pharmaceutical studies, vaccine development research and basic research, as well as in toxicological studies. The publication of data on the Intor:Swiss mice represents a contribution to the international scientific community, since it offers the possibility for obtaining an additional outbred mouse stock for research.