Volume 75 (2025) Issue: 2025 No#2

Comparison of the effects of autologous cytokine-rich serum (ACRS) and platelet-rich plasma (PRP) on skin wound healing

Author(s): Hanifi Erol, Erol Karakas, Mustafa Ermis, Gokhan Akcakavak, Nevzat Emre Aslan, Ozhan Karatas

Keywords:rat, wound, PRP, ACRS

Wound healing is one of the most complex biological events, involving physiological processes such as tissue restoration and intricate cellular and molecular activities. The aim of this study was to investigate the effects of Autologous Cytokine Rich Serum (ACRS) and Platelet-rich plasma (PRP) on wound healing and to compare their impact on tissue repair using histopathological and immunohistochemical methods. A total of 42 healthy Wistar-Albino rats were used as material. The histopathological and immunohistochemical evaluations showed that ACRS is more effective than PRP on wound healing. The superior efficacy of ACRS is attributed to its stimulation of anti-inflammatory cytokines and provision of essential nutrients such as amino acids, vitamins, and lipids. Further detailed studies are recommended to explore these findings.