Volume 63 (2013) Issue: 2013 No#5-6

THE EFFECT OF THE INTENSITY OF PARASITIC INFECTION WITH Strongyloides papillosus AND ALBENDAZOLE THERAPY ON BIOCHEMICAL PARAMETERS IN SHEEP BLOOD

Author(s): DIMITRIJEVIĆ B, BOROZAN SUNČICA, JOVIĆ S, BACIĆ D, KATIĆ-RADIVOJEVIĆ SOFIJA, STOJANOVIĆ S, SAVIĆ MILA

Keywords:albendazole, biochemical parameters, liver, sheep strongyloides papillosus

The aim of this report was to study the biochemical parameters in sheep blood under conditions of various intensities of parasitic infection with Strongyloides papillosus, as well as after therapy with albendazole (ABZ). Investigations were performed on sheep of the Würtemberg race (n = 30) in which were detected mild, moderate and high intensities of parasitic infection with S. papillosus. The control group (n = 10) was composed of sheep negative to parasitic infections. The degree and type of changes were monitored by determining the concentrations of glucose, total proteins, albumin, A/G ratio, AST, urea, total bilirubin, calcium, phosphorus, total LDH activity and isoenzymatic LDH1-5 distributions. On the basis of the obtained results, we determined, through isoenzymatic LDH distribution, that during parasitic infection with S. papillosus, there is ongoing damage to the liver, heart muscle and lung, while after therapy with ABZ, the liver suffers the most damage. The concentration of glucose, total proteins and albumin fell linearly with the rise in the intensity of parasitic infection (p<0.05), while after therapy with ABZ, the fall of these parameters was at a statistically significantly higher level (p<0.01). The activity of AST, concentration of urea and total bilirubin also rose linearly with the intensity of parasitic infection (p<0.05). After therapy with ABZ, the activity of AST and the concentration of total bilirubin were at a statistically significantly higher level (p<0.001), while the concentration of urea retained the same levels as in the case of parasitic infection. Values of calcium concentrations (p>0.05) and phosphorus (p<0.05) also fall linearly with the rise of the intesity of the parasitic infection. The trend in the concentration fall of these macroelements, continues also after treatment with albendazole (p<0.001). Having in mind our previous studies in the field of oxidative stress and phenomena lying behind these changes, we strongly recommend that in antiparasitic treatment protocols, beside antihelminthics, compounds with antioxidative properties should also be used.